PDRN Market is Booming: The market of synthetic biology is expanding explosively and raw material innovation is taking place with what is considered to be an exceeding potential scale of RMB 300 million

Created on 01.27

PDRNis not only extracted from the germ cells of salmon but also from plants and microbes. It is emerging as a new product of choice in the beauty and medical industries because of its healing ability on tissues and its anti-inflammatory attributes.

Whereas the low-molecular-weight polynucleotide segment, PDRNis highly similar to human DNA in structure and has a low immune response and minimal toxicity. PDRN was initially extracted from germ cells of salmon, but it is currently produced en masse in synthetic biology and it is a major skin healing and tissue regeneration agent.

The worldwide PDRN market is experiencing rapid expansion. The size of the global PDRN market reached RMB 180 million in 2023. The market size is expected to increase to RMB 3000 million by 2030, with an annual growth rate of 43%. The worldwide market has almost 4,000 brands which have introduced an estimated 17,000 products which contain PDRN.

The three-stage development of PDRN technology began with animal extraction and progressed to synthetic biology.

The extraction technology of PDRNhas evolved three major developments: the first generation employs animal extraction, the second generation utilizes microbial fermentation, and the third generation enters the synthetic biology period.

The traditional PDRN is extracted from the germ cells of salmon or the testes of salmon with a content of over 99%, which occurs as white powder or fibrous solid. This method of animal extraction has technical problems, which include limited supply, unknown structure and purity problems.

The synthetic biology technology allows the production of PDRN by microbial fermentation, and chemical synthesis in the place of animal based. This method allows the production of PDRN with specific sequences, high purity, and consistent quantity.

Literature over the last few years has established that the same bioactivePDRNcan be extracted from microalgae and higher plants. The molecular weight of PDRN derived from Chlorella is 1/20th that of salmon PDRN (24 kDa) and it has the same effect on wound closure and anti-photosenescence ability on reconstructed human skin models and in vitro skin tissues.

Synthetic biology technology has been recently developed to generate correct sequences of PDRN that do not originate from animals. This technology facilitates sizable production but retains the entire process starting with design and ending with fabrication. The strand synthesized PDRN has been shown to possess the desired effect of up-regulating the expression of vascular endothelial growth factor.

PDRN works in two ways: the salvage pathway and the adenosine A2A receptor activation. The salvage pathway makes nutrients available that allow the damaged cells to create new DNA, so that the process of repair is accelerated. This is a cellular DNA raw material pool. When damaged cells cannot create DNA from scratch, the recycled nutrients of PDRN accelerate the fixing of DNA by the cells. Also referred to as a cellular DNA raw material pool, PDRN provides the nutrients required to the cells to create DNA through the salvage pathway, which helps in the growth of the cells.

At the same time, as an agonist of the adenosine A2A receptor,PDRNcontrols the proportion of inflammatory and repair factors by the activation or inhibition of multiple signaling pathways with full-link regulation between anti-inflammation and collagen regeneration.

This endogenous regeneration pathway has higher technical barriers and is less dangerous than exogenous stimulation.

It also performs numerous biological actions: facilitating cell growth and anti-apoptosis, suppressing the expression of pro-inflammatory factors, facilitating the restoration of blood flow, and decelerating the aging process of the body. Under conditions of oxidative stress,PDRNis able to suppress the expression of matrix metalloproteinase genes, reduce oxidative stress in the skin, and consequently produce anti-aging effects.

PDRN has been clinically used in the treatment of various diseases, including diabetic foot ulcers, soft tissue ulcers, colitis, and arthritis. In the treatment of diabetic foot ulcers, studies have shown that an intramuscular injection of PDRN doubles the probability of ulcer healing in patients within 8 weeks compared with the placebo group. PDRN can also effectively enhance tissue oxygenation and angiogenesis around diabetic foot ulcers.

Burn treatment studies have demonstrated that PDRN can substantially enhance the microvessel density in a mouse model of deep second-degree scalds, and can speed up the re-epithelialization of burn wounds, and can reduce the time required to close the wounds.

Cosmetic Field Development

PDRN is an emerging trend in the aesthetics and the professional field has been embraced in the skin care market. In 2025, PDRN will have been employed by 3,894 brands and the quantity of products with the same ingredient will have reached 16,901 products.

The industry has shifted from the traditional monotonous products such as masks and serums to provide a wide variety of products in the market. It comprises toners, lotions, creams, ampules, and eye creams, which offer total skincare. At the same time, prices have also diversified such that consumers can access inexpensive goods at below 100 RMB and high-value goods at prices of up to 3000 RMB.

The major issue of PDRN in cosmetic use is that it does not cross the skin effectively. Because of its high molecular weight and great polarity, the absorption rate of the conventional topical application is less than 0.5%; meanwhile, the medical requirement of subcutaneous concentration to be effective should be 5 g/ml.

To resolve this issue, the market offers three primary solutions that include microspherization technology and vesicle technology of lactic acid bacteria and multi-component transdermal carrier technology. Skin absorption efficiency can be highly enhanced by compressing macromolecularPDRNand collagen to microspheres, or by converting PDRN to a ball structure with specific condensation technology, which increases skin barrier repair effect.

The international PDRN market demonstrates a competitive trend of diversified technological development and growth of production capacity in Asia-Pacific. The global PDRN market value stood at USD 72 million in 2024 and it is projected to grow to USD 540 million by 2031, with a CAGR of 32.5% between 2025 and 2031.

The Asia-Pacific region has become the largest market ofPDRNworldwide. The two markets that have the highest increase are the Chinese and South Korean markets. The Chinese market is estimated to account for 34% of the worldwide PDRN market in 2029.

Future Development Trends

The development ofPDRNtechnology will focus on three primary goals, which are precise efficacy, green production, and application in a systematic manner.

The contest in the future will focus on the more precise, greener, and systematic application of PDRN to better fight against. The companies which do not have good design and experimentation competence will encounter difficulties in entering the premium repair market.

Synthetic biology will serve as one of the major driving forces in the development ofPDRN. Certain companies have started filing patents on specific sequence nucleic acid molecules, moving the research, development, and utilization of PDRN out of the traditional extraction process optimization to the new phase of precision design.

The PDRN will be the next standard skin care product after hyaluronic acid and collagen due to technological development and high level of market training. It will also generate greater value in beauty, medicine and health.

The development path ofPDRNdemonstrates the way in which bioactive ingredients are spreading out of the professional medical field to the mainstream consumer environment. The advancement in genetic engineering and synthetic biology will allow PDRN to find new application areas in precision medicine, tissue engineering and regenerative medicine.

Industry reports indicate that the international market will become more receptive to PDRN as green extraction technology continues to advance and industry standards continue to improve. Health entrepreneurs and investors who need new investment opportunities should pay significant attention to the contemporary development of this bioactive compound.

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