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The Innovative Applications and Market Development of Glutathione from Yeast in the Dietary Supplement Industry
Created on 02.26
Recently, the trend toward improving health and beauty by eating functional foods has caused a major change in the way dietary supplement ingredients are being developed. In addition to its antioxidant properties, yeast-derived glutathione is an ingredient that is being used more frequently in the dietary supplement market because of its high level of biosafety. Dietary supplement manufacturers are showing an interest in using yeast-derived glutathione within their formulations because of its high level of biosafety and its powerful antioxidant properties.Shaanxi New Things Biotech, as a provider of raw materials for other manufacturers, has done a great study on the origin, core and broad effects of this "star" ingredient. Natural yeast based glutathione products that have been produced through the use of modern biotechnology (fermentation) and that are being used to manufacture dietary supplement products, are obtained from a fermentation process of the yeast Saccharomyces cerevisiae. Through strain screening and fermentation process optimization, scientists enable yeast cells to efficiently accumulate glutathione during growth.
Compared with chemically synthesized or animal- and plant- extracted glutathione,yeast-derived glutathionepresents distinct natural advantages. It features excellent solubility, high stability, and superior biocompatibility. In 2025, “glutathione-enriched yeast” was officially approved as a common food raw material, marking authoritative recognition of its application in food sectors including dietary supplements, and providing compliant and efficient innovative pathways for brand owners.
Core Efficacy: Beyond Antioxidation, a Multidimensional Health Guardian
Glutathioneis a tripeptide molecule composed of glutamic acid, cysteine, and glycine. As the most abundant endogenous antioxidant in the human body, its applications in dietary supplements are mainly concentrated in the following areas: Oral Beauty: Improving Skin Condition from the Root: Driven by the “face-value economy”, oral beauty has become one of the fastest-growing segments in the dietary supplement industry.
Scientists screened and cultivated yeasts that could accumulate glutathione during growth and optimized their fermentation processes. Compared to chemically synthesized or animal- and plant-based glutathione, yeast-derived glutathione shows unique advantages owing to its natural origin. It has good water solubility, stability, and compatibility. In 2025, glutathione-rich yeasts were approved as ordinary food ingredients, a milestone of official recognition of their usage as food ingredients and supplements, and offered new legal and efficient ways for companies to develop products with them.
Glutathione is a tripeptide, consisting of glutamic acid, cysteine, and glycine, and is the most abundant intracellular antioxidant in the human body. It is commonly used as a dietary supplement and has two major applications, which are:
Oral Beauty: Refers to The Improvement of Skin Condition: Oral Beauty Consumption is Growing Rapidly. The fast-growing sector of the face-value market has made oral beauty one of the fastest-growing categories of dietary supplements. Natural glutathione does three things: (a) stops melanin production, (b) provides anti-oxidative protection and (c) restores/renews/repairs the skin. First, glutathione binds to tyrosinase and stops it from making melanin. It also helps turn dark melanin into light melanin (pheomelanin) for a lighter skin tone. Second, glutathione’s unique sulfhydryl structure scavenges free radicals and stops photo damage (sun damage) from becoming pigmentation. Third, continuous supplementation of glutathione has been showed to improve skin elasticity and reduce wrinkles in human clinical trials and animal studies show it thickens the epidermis and helps to rebuild youthful skin by restoring collagen and elastin fibers in the dermis.
The liver support market is growing due to a combination of increasing liver disease, the social drinking culture that has created a rigid lifestyle need/demand for liver support products. Glutathione is concentrated mainly in the liver; it plays an active role in the protection of cells against the effects of toxins and alcohol.
Detoxification benefits
Glutathione is involved in the redox reactions that occur within our bodies, binds to toxic molecules, and helps the liver to neutralize and eliminate toxic substances like acetaldehyde to protect the liver cells.
Damage repair
Studies have shown that yeast extract intervention has significantly reduced the levels of serum ALT and AST, and the deposition of lipid droplets in hepatocytes and has effectively relieved the liver injury and inflammatory infiltration caused by ethanol.
Many Uses as a Dietary Supplement
Yeast-based glutathione represents a pure source of glutathione, and its effectiveness makes it an excellent ingredient for use in various forms:
Oral beauty liquids/tablets: These are for high-end beauty beverages targeted at skin whitening and fading of spots and anti-glycation.
Compound enzymes/solid drinks: In conjunction with other antioxidant components to strengthen the body's immunity and detoxification capacity.
Liver care capsules:Glutathioneserves as the main ingredient of these products and it is developed for individuals who drink alcohol regularly or lack proper sleep. In the field of sports nutrition, athletes use this product to help them (1) remove free radicals, and (2) recover quickly after intense physical activity.
The market is fast growing, a golden track. According to market research, the global sales of“yeast-based” glutathionewill reach approx. $35.22 million in 2024 and are expected to reach US$68.13 million in 2031, with a CAGR of 9.2% between 2025 -2031. The growth of the global sports nutrition market is being driven by two main factors. The first factor is the upgrading of consumption and health consciousness. For example, the global oral beauty market will reach USD 15 billion by 2032, and the Chinese oral beauty market will exceed RMB 25 billion by 2025. Consumers are looking for clean labels and natural ingredients. Due to this reason, more consumers choose glutathione from yeast rather than synthetically produced glutathione ones. The raw material has been legalized in major markets and at the same time the upstream fermentation and purification technologies have been matured (high content, high bioavailability, high purity products have been developed), yeast glutathione has been transformed from an optional additive into a core functional ingredient. At present, Asia and the Pacific, especially China and Japan, are the largest markets for the consumption of this raw material.
The window of opportunity for innovative product development in downstream dietary supplement companies is continually expanding due to market education initiatives from leading established industry leaders like Ajinomoto and Angel Yeast. The reasons for selectingShaanxi New Things Biotechinclude the fact that quality and stability are the foundation of brands in the functional raw material industry. Our experience in plant and biotech extracts allows us to offer you high purity/high content yeast glutathione through strict quality control systems and R&D capabilities. Complete audit trails and compliance documentation will be provided to assist with the registration and marketing of finished products in a global manner. We also provide customized services to assist you and your R&D team to create new formulations or improve existing product dosage forms.
Conclusion:
Yeast-derived glutathione offers great support for the oral beauty industry and for liver health. It provides both basic nutrition and targeted functions. AtShaanxi New Things Biotech, we are excited to work with our partners from around the world to utilize this incredible "tiny giant" in all the innovative products that we develop together, and to explore the growing health market. Contact us for more samples and technical documents on yeast-based glutathione.
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